Efficacy and Safety of Apixaban Compared With Warfarin According to Patient Risk of Stroke and of Bleeding in Atrial Fibrillation: A Secondary Analysis of a Randomised Controlled Trial

Study Questions:

What is the safety and efficacy of apixaban compared with warfarin for stroke prevention in atrial fibrillation in the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) study, according to patients’ CHADS2, CHA2DS2VASc, and HAS-BLED scores used to predict the risk of stroke and bleeding?