Effects of Body Size and Hypertension Treatments on Cardiovascular Event Rates: Subanalysis of the ACCOMPLISH Randomised Controlled Trial

Study Questions:

In high-risk hypertensive patients, paradoxically higher cardiovascular event rates have been reported in patients of normal weight compared with obese individuals. A prespecified analysis of the ACCOMPLISH (Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension) trial was conducted to determine whether the type of hypertension treatment affects patients’ cardiovascular outcomes according to their body mass index (BMI = kg/m2).