Results:

The authors identified two randomized controlled trials, one observational study with a control group, and nine observational studies without a control group. A total of five different catheters were used across these trials. In controlled studies, there was a reduction in mean systolic (-28.9 mm Hg; 95% confidence interval [CI], -37.2 to -20.6; p < 0.0001) and diastolic (-11.0 mm Hg; 95% CI, -16.4 to -5.7; p < 0.0001) blood pressure (BP) at 6 months compared to medically treated patients. In uncontrolled studies, there was a similar reduction in mean systolic (-25.0 mm Hg; 95% CI, -29.9 to -20.1) and diastolic (-10.0 mm Hg; 95% CI, -12.5 to -7.5) blood pressure at 6 months compared to pre-RDN values. There was no difference in the effect of RDN according to the type of the device used. Reported procedural complications included one renal artery dissection and four femoral pseudoaneurysms.