Effects of a Fixed-Dose Combination Strategy on Adherence and Risk Factors in Patients With or at High Risk of CVD: The UMPIRE Randomized Clinical Trial

Study Questions:

Does the use of a fixed-dose combination of aspirin, statin, and two blood pressure–lowering agents versus usual care improve long-term adherence to indicated therapy and two major cardiovascular disease (CVD) risk factors, systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C), among patients with CVD?