Results:

A total of 220 consecutive patients with first MI and percutaneous coronary intervention (PCI) were screened between March 2009 and June 2011. After exclusions (shock, unable to follow-up, need for surgery, severe medical illnesses, lack of consent, no sleep study or CMR), 56 patients were enrolled. SDB was found in 29 (52%) and not in 27 patients. There was no significant difference between the SDB and no SDB groups with respect to age, gender, coronary risk factors, and hemodynamic findings. Patients with SDB had higher body mass index and left ventricular mass compared with no SDB. There were no significant differences for time from symptom onset to revascularization, infarct-related artery, TIMI flow pre- or post-PCI, thrombus aspiration, or use of glycoprotein IIb/IIIa inhibitors during PCI. All patients were on optimal medical therapy. One patient without SBD had recurrent MI during follow-up.The area at risk between both groups was similar (40 ± 12% vs. 40 ± 14%, p = 0.925). Patients with SDB had significantly less salvaged myocardium (myocardial salvage index 52% vs. 77%, p < 0.001), smaller reduction in infarct size (0.3% vs. 6.5%, p < 0.001) within 3 months after acute MI, a larger final infarct size (23% vs. 12%, p < 0.001), and a lower final left ventricular ejection fraction (48% vs. 54%, p = 0.023). In a multivariate analysis, including established risk factors for large MI, AHI was independently associated with less myocardial salvage and a larger infarct size 3 months after acute MI.