Comparison of a Novel Method vs the Friedewald Equation for Estimating Low-Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile

Study Questions:

The Friedewald equation used to derive the low-density lipoprotein cholesterol (LDL-C) from the fasting lipid profile is based on the very low-density lipoprotein cholesterol (VLDL-C) being calculated as triglycerides/5 (TG:VLDL-C = 5). The authors sought to derive and validate a more accurate method for estimating LDL-C by using an adjustable factor for the TG:VLDL-C ratio.