Reduced Anticoagulation After Mechanical Aortic Valve Replacement: Interim Results From the Prospective Randomized On-X Valve Anticoagulation Clinical Trial Randomized Food and Drug Administration Investigational Device Exemption Trial

Study Questions:

What is the safety and efficacy of less aggressive anticoagulation with an international normalized ratio (INR) goal of 1.5-2.0 in high-risk patients following bileaflet mechanical aortic valve replacement, compared to standard anticoagulant therapy with an INR goal of 2.0-3.0?