Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

Study Questions:

Are resveratrol levels associated with inflammation, cancer, cardiovascular disease, and mortality among adults?

Methods:

Data were from the InCHIANTI (Invecchiare in Chianti) study, a prospective cohort study conducted in two villages in the Chianti area of Italy between 1998 and 2009. Community dwelling adults ages 65 years or older were included. Twenty-four hour urinary resveratrol metabolites were measures in each subject. The primary outcome of interest was all-cause mortality. Secondary outcomes of interest included markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.

Results:

A total of 783 men and women were included in this study. Mean (95% confidence interval [CI]) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. More men were in the highest quartiles of total urinary resveratrol metabolites than women. Alcohol consumption, current smoking, and physical activity were higher among participants in the highest quartile of total urinary resveratrol metabolites compared with the lower quartiles. The prevalence of coronary artery disease and diabetes was higher among those in the lowest quartile of total urinary resveratrol metabolites. Over 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (p = 0.67). Participants in the lowest quartile had a hazard ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.

Conclusions:

The investigators concluded that in older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, cancer, or all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.

Perspective:

These data suggest that resveratrol does not reduce risk for cardiovascular or cancer events. However, this cohort did not include those using supplements which contain resveratrol; further trials would be needed to examine supplementation beyond dietary forms of resveratrol.

Clinical Topics: Prevention, Atherosclerotic Disease (CAD/PAD), Diet, Smoking

Keywords: Inflammation, Coronary Artery Disease, Neoplasms, Follow-Up Studies, Interleukin-6, Tumor Necrosis Factors, Creatinine, Smoking, Prevalence, C-Reactive Protein, Proportional Hazards Models, Research Personnel, Stilbenes, Motor Activity, Diet, Health Status, Diabetes Mellitus


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