Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabetes

Study Questions:

In a population of patients with type 2 diabetes mellitus on metformin, what is the comparative difference in time to acute myocardial infarction (AMI), stroke, or death in those who intensify their therapy with insulin versus a sulfonylurea?