Results:

A total of 607 patients who received medical therapy alone were included in this analysis. Risk factors for coronary artery disease were common in the study population. No significant differences in risk factors were experienced between patients who experienced MACE or not, with the exception of angina class. MACE was associated with increased complex stenosis. FFR values were mostly distributed in the range between 0.70 and 0.90. MACE occurred in 272 (26.5%) out of 1,029 lesions. Target lesions with diameter stenosis ≥70% were more frequent in the MACE group (p < 0.01). Median FFR was significantly lower in the MACE group versus the non-MACE group (0.68 [interquartile range, 0.54-0.77] vs. 0.80 [interquartile range, 0.70-0.88]; p < 0.01). The cumulative incidence of MACE significantly increased with increasing FFR quartiles. An average decrease in MACE per 0.05 unit increase in FFR was statistically significant even after adjustment for all clinical and angiographic features (odds ratio, 0.81; 95% confidence interval [CI], 0.76-0.86]). The strongest increase in MACE occurred for FFR values between 0.80 and 0.60. In multivariable analysis, FFR was significantly associated with MACE up to 2 years (hazard ratio, 0.87; 95% CI, 0.83-0.91).