Can a newer, more targeted pacing method revolutionize heart failure treatment? The PhysioSync-HF trial investigates conduction system pacing as a potentially more effective and affordable alternative to traditional cardiac resynchronization therapy. Explore the surprising differences between this study and prior research and hear firsthand what it was like to lead a nationwide, publicly funded clinical trial across Brazil. This episode dives deep into innovation, equity, and the future of heart care.

In this interview, Drs. Joseph Marine and André Zimerman discuss “PhysioSync-HF: Conduction System vs. Biventricular Pacing in Cardiac Resynchronization in HFrEF”.

Related References:

1. Zimerman A, Dal Forno A, Rohde LE, et al. Conduction system pacing vs biventricular resynchronization in heart failure with reduced ejection fraction and left bundle branch block: Rationale and design of the PhysioSync-HF Trial. Am Heart J. 2025;290:38-45. doi:10.1016/j.ahj.2025.06.002
2. Whinnett Z, Naraen A, Vijayaraman P, Cleland JGF, Keene D. Physiological pacing: mechanisms, clinical indications, and perspectives. Eur Heart J. Published online July 18, 2025. doi:10.1093/eurheartj/ehaf440