Impact of Alcohol Abstinence in Moderate Drinkers With Atrial Fibrillation - Alcohol-AF
Contribution To Literature:
The Alcohol-AF trial showed that abstinence from alcohol was beneficial at preventing atrial fibrillation recurrence.
The goal of the trial was to evaluate abstinence from alcohol compared with usual consumption among patients with atrial fibrillation and moderate alcohol consumption.
Patients with atrial fibrillation and regular moderate alcohol consumption were randomized to abstinence (n = 70) versus usual consumption (n = 70).
- Total number of enrollees: 140
- Duration of follow-up: 6 months
- Mean patient age: 62 years
- Percentage female: 13%
- Percentage with diabetes: 7%
- Paroxysmal or persistent atrial fibrillation
- Average alcohol intake ≥10 drinks per week
- Permanent atrial fibrillation
- Left ventricular ejection fraction <35%
- Alcohol dependence or psychiatric comorbidity
- Liver cirrhosis
Other salient features/characteristics:
- Average alcohol intake approximately 16 drinks per week
The co-primary outcome, atrial fibrillation recurrence, occurred in 53% of the abstinence group compared with 73% of the usual consumption group (p = 0.004).
The co-primary outcome, mean atrial fibrillation burden, was 5.6% of the abstinence group compared with 8.2% of the usual consumption group (p = 0.016).
- Atrial fibrillation hospitalization: 9% of the abstinence group compared with 20% of the usual consumption group (p = 0.053)
- Body mass index (BMI) at follow-up: 27.7 kg/m2 in the abstinence group compared with 28.9 kg/m2 in the usual consumption group (p = 0.03)
Among patients with atrial fibrillation and moderate alcohol consumption, abstinence from alcohol was associated with a reduction in atrial fibrillation recurrence and atrial fibrillation burden. Abstinence was also associated with a reduction in BMI at follow-up. Patients with atrial fibrillation should be counseled on limiting alcohol consumption.
Presented by Dr. Aleksandr Voskoboinik at the American College of Cardiology Annual Scientific Session (ACC 2019), New Orleans, LA, March 18, 2019.
Keywords: ACC19, ACC Annual Scientific Session, Alcohol Abstinence, Alcohol Drinking, Arrhythmias, Cardiac, Atrial Fibrillation, Body Mass Index, Ethanol, Primary Prevention
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