The implementation of generative artificial intelligence (AI) and large language models in health care continues to expand. The National Academy of Medicine Digital Health Action Collaborative held a workshop in October of 2023 to define applications and frameworks for generative AI and large language models in medicine and biomedical science. In a recent article published in NEJM, Thomas M. Maddox, MD, MsC, FACC, et al., describe how new advances build on their previous report, expanding knowledge on the best practice to adapt these new technologies into health, medicine and biomedical science. Read the full article.