In an episode of the AI-Enabled Clinician podcast, Ami B. Bhatt, MD, FACC, and Srinath Adusumalli, MD, FACC, discuss the integration of large language models in health systems. Adusumalli shares his first-hand experience from Penn Medicine, highlighting Penn Medicine’s transition from predictive AI to generative AI by leveraging a clinical team-led approach. They also explore the shifting dynamics of prompt engineering and the importance of multi-phase monitoring to ensure AI safety guardrails. Listen now.