The new CKM Syndrome Guideline Spotlight Issue published in JACC features expert perspectives on the recent 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome, including practical guidance on heart failure prevention, obesity management, and the use of SGLT2 inhibitors and GLP-1–based therapies in clinical practice. Read the full issue.

Also access a new case scenario slide set on the CKM Syndrome Guideline Hub that illustrates the practical application of the Guideline through real-world patient case scenarios. The slide set walks through key clinical decision points, and evidence-based management strategies anchored to key guideline recommendations. Available to download for rounds, presentations or other educational activities, the cases help clinicians identify, stage and manage CKM syndrome to improve cardiovascular, kidney and metabolic health outcomes. Download the slides.