Coronary artery calcium (CAC) scoring provides important prognostic value, particularly for individuals at intermediate risk for coronary artery disease (CAD) or those with a family history of the condition. Incorporating computed tomography calcium scoring into a structured disease‑management program may help prevent the progression of coronary plaque, although this strategy has not yet been evaluated in a randomized trial.

In this interview, Allen J. Taylor, MD, FACC and Dr Nitesh Nerlekar, MBBS, PHD discuss the CAUGHT-CAD Randomized Trial: Effects of Combining Coronary Calcium Score with Treatment on Plaque Progression in Familial CAD”.

Related References:

1. Nerlekar N, Vasanthakumar SA, Whitmore K, et al. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial. JAMA. 2025;333(16):1403-1412. doi:10.1001/jama.2025.0584
2. 2. Blaha MJ. Filling the Evidence Gaps Toward a Coronary Artery Calcium-Guided Primary Prevention Strategy. JAMA Cardiol. 2025;10(5):411-413. doi:10.1001/jamacardio.2025.0410
3. 3. Nasir K, Blankstein R. Transforming the Cardiovascular Disease Prevention Paradigm: See Disease, Treat Disease. JAMA. 2025;333(16):1398-1400. doi:10.1001/jama.2025.2323