Mixed cardiogenic-vasodilatory shock is common in the contemporary cardiac intensive care unit. In a recent state-of-the-art review published in JACC: Advances, Jacob Colin Jentzer, MD, FACC, et al., discuss the potential etiologies, pathophysiology and management of mixed cardiogenic-vasodilatory shock in the context of a proposed novel classification system. Further research is still needed to improve outcomes for patients with mixed shock. Read the full article.