The latest issue of JACC highlights the continued evolution of sex-informed cardiovascular care and raises important questions about age, treatment patterns and cardiovascular risk in women. The issue features research exploring how menopausal status influences vascular responses to chemotherapy, as well as how the use of a microaxial flow pump affects outcomes in women. It also includes a state‑of‑the‑art review highlighting key gaps in the understanding of sex differences in dilated cardiomyopathy and more. Read the full issue and tune in to the latest episode of the JACC This Week podcast for an in-depth discussion.