In the GALACTIC-HF trial of 8,256 patients with heart failure (HF) and reduced ejection fraction (EF), omecamtiv mecarbil significantly improved the primary endpoint of time to first HF event or cardiovascular death without any adverse effect on blood pressure, heart rate, potassium homeostasis, or renal function and without increases in ischemic cardiac events or arrhythmias. In this interview, Michelle O'Donoghue, MD, FACC; John Teerlink, MD, FACC; and Jeffrey Hsu, MD, PhD, discuss the effect of EF on clinical outcomes in patients treated with omecamtiv mecarbil in the GALACTIC-HF trial.

Clinical Topics: Arrhythmias and Clinical EP, Heart Failure and Cardiomyopathies, Implantable Devices, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Acute Heart Failure

Keywords: ACCELLite, Heart Failure, Stroke Volume, Heart Rate, Blood Pressure, Ventricular Dysfunction, Left, Arrhythmias, Cardiac, Homeostasis

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