Journal Wrap | ALONE-AF; HI-PRO; More
The hottest research from various peer-reviewed journals – handpicked weekly by the ACC.
ALONE-AF: When to Stop OAC After Successful Ablation, No Arrhythmia Recurrence
Discontinuing oral anticoagulant (OAC) therapy in patients with no documented atrial arrhythmia recurrence one year after catheter ablation for atrial fibrillation (AFib) resulted in a lower risk for the composite of stroke, systemic embolism (SE) and major bleeding vs. continuing direct oral anticoagulant therapy (DOAC), based on results from the ALONE-AF trial presented at ESC Congress 2025 and simultaneously published in JAMA.
HI-PRO: Apixaban Lowers VTE Risk in Patients With Transient Provoking Factors
At one year, low-intensity apixaban therapy results in lower risk of symptomatic recurrent venous thromboembolism (VTE) vs. placebo in patients with provoked VTE and enduring risk factors. Furthermore, it carries a low risk of major bleeding, according to efficacy and safety results of the HI-PRO trial, presented during ESC Congress 2025 and simultaneously published in NEJM.
Essence-TIMI 73b: Olezarsen Significantly Lowers TG in Moderate HTG and Elevated CV Risk
Olezarsen significantly reduced triglyceride (TG) levels at six months vs. placebo in patients with moderate hypertriglyceridemia (HTG) and elevated cardiovascular risk, according to results of the Essence-TIMI 73b study presented during ESC Congress 2025 and simultaneously published in NEJM.
AQUATIC: Aspirin Plus OAC Results in Higher Risk of Major CV Events, Bleeding in CCS
Patients with chronic coronary syndrome (CCS) and at high atherothrombotic risk who received aspirin in addition to their current oral anticoagulation (OAC) therapy had a higher risk of cardiovascular death, myocardial infarction, stroke, systemic embolism, coronary revascularization or acute limb ischemia than those taking a placebo, according to results from the AQUATIC study presented at ESC Congress 2025 and simultaneously published in NEJM.
ESC Congress 2025 Hub
Visit the Hub at ACC.org/ESC2025 for all the coverage from the ACC.org Editorial team, including news stories, trial summaries, video roundups and more.
Clinical Topics: Acute Coronary Syndromes, Arrhythmias and Clinical EP, Diabetes and Cardiometabolic Disease, Dyslipidemia, Heart Failure and Cardiomyopathies, Prevention, Pulmonary Hypertension and Venous Thromboembolism, Vascular Medicine, Implantable Devices, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Pulmonary Hypertension, Hypertension
Keywords: Cardiology Magazine, ACC Publications, ESC25, ESC Congress, Acute Coronary Syndrome, Dyslipidemias, Secondary Prevention, Hypertension, Pulmonary, Arrhythmias, Cardiac
