Prevention of Cardioembolic Stroke in Obese Patients With Nonvalvular Atrial Fibrillation

Ms. X is a 70-year-old female with new onset non-valvular atrial fibrillation. She has a past medical history of hypertension, diabetes, hyperlipidemia and morbid obesity. BMI 43.7 kg/m2, 123 kg, 66 inches. CrCl 45 mL/min. There are no pertinent drug interactions.

According to the 2016 International Society on Thrombosis and Haemostasis guidance document, which anticoagulant is most appropriate for stroke prevention in this patient?

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