Aspirin Therapy for Primary Prevention of Cardiovascular Disease

Please use the two patient cases below to answer the assessment question.

Patient 1
65-year-old African American male patient, non-smoker
PMH: hypertension, diabetes, chronic kidney disease, anemia
Medications: lisinopril 20 mg po daily, amlodipine 5 mg po daily, metformin 1000 mg po twice daily, canaglifozin 100 mg po daily, sevelamer 800 mg po three times daily

Vitals: BP: 126/78 mm Hg, P: 68 beats per minute, BMI 23 kg/m2
Labs: Creatinine 1.9 mg/dl (baseline), A1C: 6.5%, hemoglobin 10.7 g/dL, platelets 220k
Lipids (mg/dL): Total Cholesterol: 155, Triglycerides: 144, HDL-C: 39, LDL-C: 85

Patient 2
74-year-old white female patient, non-smoker
PMH: diabetes, hyperlipidemia, osteoarthritis
Medications: Glyburide 10 mg po daily, atorvastatin 20 mg po daily, ibuprofen 200 mg po three times daily

Vitals: BP 116/74 mm Hg, P: 72 beats per minute, BMI 27 kg/m2
Labs: Creatinine 1.1 mg/dl, A1c: 7.2%, hemoglobin 12.7 g/dL, platelets 195k
Lipids (mg/dL): Total Cholesterol: 155, Triglycerides: 88, HDL-C: 55, LDL-C: 82

Which of the following patient(s) should be prescribed aspirin (75-100 mg daily) for primary prevention of cardiovascular disease according to the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?

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