Genotype-Guided Treatment With Oral P2Y12 Inhibitors

A 68-year-old Caucasian male patient presented to the emergency room with crushing chest pain, diaphoresis, and dyspnea. Chest pain was substernal, rated 7/10 in intensity, and radiating to both arms. Pain improved with administration of nitroglycerin. The patient was a former smoker with insulin-dependent type 2 diabetes mellitus, hypertension, and hyperlipidemia. He had been treated with percutaneous coronary intervention (PCI) with an earlier-generation drug-eluting stent to the left anterior descending artery 12 months ago for an anterior wall myocardial infarction (MI). An echocardiogram post-PCI showed normal left ventricular systolic function. He was treated with aspirin 81 mg daily, clopidogrel 75 mg daily, and atorvastatin 80 mg daily.

On exam, his body mass index was 30 kg/m2, temperature was 98.1° F, heart rate was 95 bpm, and blood pressure was 100/70 mmHg. The remainder of the cardiovascular exam was otherwise unremarkable. The patient stated that he had one episode of self-terminated gastrointestinal bleed 7 months prior and had briefly interrupted his antiplatelet therapy for 2 weeks. His electrocardiogram showed normal sinus rhythm with new ST-segment elevation with Q waves in leads V2-5 and reciprocal ST-segment depressions in leads III and aVF. Bedside echocardiogram showed new wall motion abnormality in the anterior wall. The patient was emergently taken to the cardiac catheterization laboratory and found have late stent thrombosis of the left anterior descending artery stent.

Which of the following is not true pertaining to this patient's current presentation?

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