Treatment of Venous Thromboembolism in Malignancy

A 62-year-old female with a history of smoking, hypertension, hypothyroidism, and recently diagnosed with non-small cell lung cancer of the right lung presents to your outpatient clinic for evaluation. She is currently undergoing treatment with nivolumab/ipilimumab. Her oncologist noted left lower extremity swelling and pain at a clinic visit 1 week ago and obtained a venous duplex ultrasound of the leg demonstrating a left femoral deep venous thrombosis.

The patient appears comfortable, has an oxygen saturation of 98% on room air, respiratory rate of 20 breaths per minute, blood pressure of 115/72 mmHg, and heart rate of 68 beats per minute. She is afebrile. Her weight is 68 kg. Her current medications include carvedilol and levothyroxine. Her creatinine clearance is 55 mL/min, hemoglobin 12.5 g/dL, and platelet count is 257 thousands/uL.

Which of the following is the most accurate statement regarding the treatment of this patient?

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