History of Presenting Illness:
A 64-year-old man is referred for systolic murmur and abnormal echocardiogram. He has a history of hypertension. He does not smoke, is physically active (walks briskly for three miles per day), and consumes a healthy diet. He has no symptoms. Medications include aspirin, high-intensity statin (atorvastatin), and angiotensin converting enzyme inhibitor. Blood pressure is 120/80 mmHg and heart rate is 65 beats per minute.
Figure 1 |
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Electrocardiogram (ECG):
Sinus rhythm, normal axis and intervals, no ST-segment abnormalities
Echocardiogram:
Normal biventricular systolic function, ejection fraction 60-65%, with mild concentric LVH
Normal biatrial size
Heavily calcified aortic valve, unable to discern valve morphology; Vmax 5 m/s, peak gradient 99 mmHg, mean gradient 60 mmHg, calculated aortic valve area 0.5 m2. (Figure 1)
Pulmonary artery systolic pressure is 28 mmHg based on an RA pressure of 5 mmHg.
The correct answer is: B. Refer for transcatheter aortic valve replacement.
The correct answer is B (choice B is NOT an appropriate clinical option). Answer A is a reasonable clinical option; based on current AHA/ACC guidelines, surgical aortic valve replacement is reasonable (class IIa) for patients with asymptomatic very severe AS (defined as Vmax ≥ 5 m/s or mean gradient ≥ 60 mmHg). Answer C is a reasonable clinical option; exercise testing also is reasonable (class IIa) to confirm asymptomatic status and to assess hemodynamic response to exercise. Answer D also is a reasonable clinical option; neither surgical aortic valve replacement nor exercise testing in this scenario is a class I recommendation. Answer B is incorrect because transcatheter aortic valve replacement is approved (in the United States) only for inoperable and high-risk patients. This patient is not at high risk for surgical aortic valve replacement.
Reference
- Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol. 2014;63(22):e57-e185.