What is Wrong With That Aortic Valve?
A 63-year-old woman with severe aortic stenosis and coronary artery disease underwent coronary artery bypass grafting and aortic valve replacement with a 19 mm bioprosthetic valve. Her postoperative course was uncomplicated, and an echocardiogram done 1 month postoperatively demonstrated a well-seated prosthetic valve in the aortic position with a peak gradient of 20 mmHg, a mean gradient of 10 mmHg, and no aortic regurgitation. Two years after surgery, she presented to an outpatient cardiology clinic complaining of dyspnea on exertion and two-pillow orthopnea for several weeks. She denied chest pain, palpitations, syncope, or lower extremity edema. Her past medical history was otherwise notable for type 2 diabetes mellitus, hypertension, peripheral artery disease, and mixed connective tissue disease. Her medications included amlodipine, hydrochlorothiazide, lisinopril, metformin, aspirin, atorvastatin, and plaquenil. Her vital signs were as follows: blood pressure of 156/62; pulse of 82 bpm; respiratory rate of 18; oxygen saturation of 98% on room air. On cardiovascular examination, the heart had a regular rhythm, S1 was normal, and S2 was split. A grade 3, mid-peaking, systolic, crescendo-decrescendo murmur was audible at the base and radiated to carotids. The jugular venous pressure was estimated at 9 cm H20 with no hepatojugular reflex. Mild crackles were appreciated in bases of the lungs. Her blood work revealed a hemoglobin of 10.9 g/dl, normal haptoglobin, and normal lactate dehydrogenase level. The patient was referred for a transthoracic echocardiogram (TTE) that revealed normal biventricular systolic function; presence of a bioprosthetic aortic valve with peak transaortic gradient of 55 mmHg and mean gradient of 32 mmHg, trace aortic regurgitation; estimated pulmonary artery systolic pressure of 57mmHg; thickening of anterior and posterior mitral leaflets with posterior mitral annular calcification; and mild-to-moderate mitral regurgitation. The maximum velocity across left ventricular outflow tract was 0.6m/sec; the maximum velocity across aortic valve was 3.6 m/sec; acceleration time of aortic valve was 115 milliseconds.
Shown below are the parasternal long axis (Video 1) and short axis views (Video 2) of the aortic valve on TTE, the transvalvular gradient Doppler profile on TTE (Figure 1), and radial multiplanar reconstruction (Figure 2) and axial minimum intensity projection (Figure 3) of aortic valve on cardiac computerized tomography (CT) scan.
What is the most likely etiology of increased transaortic valve gradients?