WOEST Trial Finds Clopidogrel Administered Without Aspirin Reduces Bleeding
In patients receiving oral anticoagulants and undergoing percutaneous coronary intervention (PCI), use of clopidogrel without aspirin was found to be associated with a significant reduction in bleeding complications and no increase in the rate of thrombotic events, according to a study published on Feb. 13 in The Lancet.
The authors note that the trial "clearly shows that clopidogrel alone administered to patients taking oral anticoagulants who require PCI is associated with a significantly lower rate of bleeding complications at one year than is use of clopidogrel plus aspirin." They add that, "although the trial was small, we saw no evidence of an increased risk of thrombotic events by withholding of aspirin."
Keywords: Blood Transfusion, Ticlopidine, Hemorrhage, Percutaneous Coronary Intervention
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