Gender Data Forum: Are DES Safer and More Effective Than Bare Metal Stents in Women?
The use of drug-eluting stents (DES) in women is more effective and safe than using bare-metal stents during long-term follow-up, according to a study released on Sept. 2 during the ESC Congress 2013 and simultaneously published in The Lancet.
In that same period, definite or probable stent thrombosis occurred in 1.3 percent, 2.1 percent and 1.1 percent of women in the bare-metal stent, early-generation DES, and newer-generation DES groups, respectively (p=0·01). The study investigators also noted that the use of DES was associated with a significant reduction in the three-year rates of target lesion revascularization.
Overall, the study authors point out that the use of newer-generation DES was associated with "significantly lower rates" of death or myocardial infarction, definite or probable stent thrombosis, and definite stent thrombosis than was the use of early- generation DES. "This analysis shows for the first time, to the best of our knowledge, that the improved outcome in women in terms of safety with newer-generation DES did not compromise but rather improved efficacy," they said. As a result, they suggest that newer-generation DES be considered the standard of care for percutaneous coronary revascularization in women.
Keywords: Incidence, Myocardial Infarction, Follow-Up Studies, Thrombosis, Drug-Eluting Stents, Standard of Care, Percutaneous Coronary Intervention
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