In patients with heart failure (HF) and severe secondary mitral regurgitation (SMR), a short-term change in disease-specific health status was associated with subsequent long-term risk of death or HF hospitalization, according to results from the COAPT study presented during ACC.20/WCC and simultaneously published in the Journal of the American College of Cardiology.

Suzanne V. Arnold, MD, MHA, et al., examined the association between change in health status from baseline to one month and the composite rate of death or HF hospitalization between one month and two years among patients in COAPT, and examined whether treatment with transcatheter mitral valve repair (TMVr) vs. guideline-directed medical therapy (GDMT) alone affected this association.

Results showed improvement in short-term, patient-reported disease-specific health status was independently associated with lower risk of subsequent death or HF hospitalization between one month and two years. Patients treated with TMVr were more likely to achieve a ≥10-point improvement in health status from baseline to one month (TMVR 58% vs. GDMT alone 26%). However, researchers found the association of health status changes with long-term outcomes did not differ by treatment assignment.

"[The] data suggest that serial assessments of health status in patients with HF and severe SMR – particularly around times of medical intensification or interventional therapy – may be beneficial to identify patients with a potentially improved prognosis or, conversely, those who remain at high risk for poor outcomes," the researchers concluded.

Clinical Topics: Cardiovascular Care Team, Heart Failure and Cardiomyopathies, Acute Heart Failure

Keywords: ACC Annual Scientific Session, acc20, Heart Failure, Mitral Valve, Patient Outcome Assessment

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