JACC in a Flash: COVID-19 Coverage

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COVID-19 Research Explores History of HF Associated With Mortality; Drive-Through Pacing Clinics

History of heart failure (HF) may be associated with higher risk of mechanical ventilation and mortality among patients hospitalized for COVID-19, regardless of left ventricular ejection fraction (LVEF), according to an article published in the Journal of the American College of Cardiology.

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Influenza Vaccine Trials Could Inform Vaccine Strategies For COVID-19

Seasonal influenza vaccine development and mass production, as well as three international trials looking at influenza vaccine cardiovascular outcomes, could inform future efforts toward developing and evaluating vaccine strategies for COVID-19, according to a state-of-the-art review published in the Journal of the American College of Cardiology.

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Since the emergence of the COVID-19 pandemic, the impact of the virus on the heart has become more prevalent, with clinicians acting in real time to effectively help cardiovascular disease patients and those at higher risk who contract coronavirus.

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Coronavirus Historical Perspective, Disease Mechanisms and Clinical Outcomes

According to a paper by Sean P. Pinney, MD, FACC, et al., most people infected with COVID-19 experience mild symptoms and recover, but the elderly and people with comorbidities are more susceptible to infection and serious illness and complications, with development of acute respiratory distress syndrome and microthrombi in the lungs, heart and kidneys appearing to be the drivers of fatal disease. Researchers said that the long-term risk of serious illness for survivors of severe cases of COVID-19 remain uncertain, but early observations are concerning.

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Coronavirus and CVD, Myocardial Injury and Arrhythmia

A separate paper by Gennaro Giustino, MD, et al., discusses the underlying mechanisms producing cardiovascular damage among hospitalized patients with severe COVID-19 infection, including that of thromboembolic disease and arrhythmia. According to researchers, myocardial injury occurs in about one-quarter of hospitalized COVID-19 patients and is associated with a greater need for mechanical ventilator support and higher hospital mortality.

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Coronavirus and Cardiometabolic Syndrome

A new COVID-19-related cardiometabolic syndrome composed of four drivers – abnormal adiposity, dysglycemia, dyslipidemia and hypertension – is discussed in a paper by Jeffrey I. Mechanick, MD, et al. Researchers give recommendations for these patients, especially those with diabetes, for preventing cardiovascular disease while navigating the COVID-19 pandemic. Recommendations include pharmacotherapy and lifestyle changes, such as diet and exercise routines, be adopted and maintained within social distancing guidelines. The researchers add that disruptions in work and school routines and the convenience of ordering in food during social distancing and stay-at-home orders can negatively impact health habits. They note that patients should receive "simple" healthy lifestyle instructions.

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Majority of COVID-19 Patients With Myocardial Injury Have Cardiac Structural Abnormalities

Cardiac structural abnormalities were present in nearly two-thirds of patients with COVID-19 and myocardial injury, according to a study published in the Journal of the American College of Cardiology.

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Thromboembolism, CV Complications Common in Hospitalized COVID-19 Patients

Patients with COVID-19 have a high frequency of major arterial or venous thromboembolism, major adverse cardiovascular events and symptomatic venous thromboembolism, despite routine thromboprophylaxis, according to a study published in the Journal of the American College of Cardiology.

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How Are Regulatory Agencies Supporting Research During COVID-19?

The COVID-19 pandemic may disrupt cardiovascular drug and device deployment, according to a report published in the Journal of the American College of Cardiology. The report discusses the central role of regulatory authorities in supporting research adaptations to the realities of the pandemic.

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Clinical Topics: Anticoagulation Management, Dyslipidemia, Geriatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Noninvasive Imaging, Prevention, Pulmonary Hypertension and Venous Thromboembolism, Vascular Medicine, Atherosclerotic Disease (CAD/PAD), Anticoagulation Management and Venothromboembolism, Lipid Metabolism, Novel Agents, Interventions and Coronary Artery Disease, Interventions and Imaging, Interventions and Vascular Medicine, Angiography, Nuclear Imaging

Keywords: ACC Publications, Cardiology Magazine, Aged, Renin, Influenza Vaccines, COVID-19, Influenza, Human, Aldosterone, Coronary Angiography, Seasons, Coronary Artery Disease, Troponin, Coronavirus, Cardiovascular Diseases, Secondary Prevention, Angiotensins, Pandemics, Retrospective Studies, Hospital Mortality, Venous Thromboembolism, Prevalence, Hyperlipidemias, Electronic Health Records, Cardiovascular Agents, Prognosis, Outpatients, Adiposity, Anticoagulants, Physician Executives


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