Post Ablation Pericarditis

Quick Takes

  • Post ablation pericarditis is a type of post cardiac injury syndrome that can be witnessed after radiofrequency or cryoablation procedures for atrial and ventricular arrhythmias.
  • Multimodality imaging is integral in the diagnosis and management of post ablation pericarditis.
  • Patients should be closely monitored after ablation procedures.


Post ablation pericarditis is a type of post cardiac injury syndrome which results from an inflammatory reaction to the myo-pericardial damage from both radiofrequency catheter as well as cryoablation for atrial and less so ventricular arrhythmias.1 The diagnosis is confirmed, in keeping with the European Society of Cardiology (ESC) guidelines, when two out of the four criteria meet: chest pain improved by sitting up or leaning forward, pericardial friction rub, new diffuse ST-segment elevation, or PR-segment depression on electrocardiogram (ECG), and new or worsening pericardial effusion.2 Available literature describing post ablation pericarditis is limited to retrospective studies and a small number of case reports and series. Therefore, we aim to review the pathophysiology, role of multimodality imaging, established literature, and treatment methods for this specific subset of patient cohort.

Pathophysiology and Clinical Presentation

Myopericarditis is an uncommon complication post ablation. Radiofrequency (RF), cryoablation, and laser ablation are some of the energy sources utilized for atrial fibrillation (AF) ablation. RF generates a lesion by heat which is transmitted via the tip of a catheter with or without saline irrigation.3 Left atrial balloon is used for cryoablation which freezes each pulmonary vein separately.4 Further, RF ablation technique for ventricular tachycardia (VT) entails either an endocardial or an epicardial approach. Pericardial complications like hemopericardium and symptomatic pericarditis can be witnessed in epicardial approach where an epidural needle is introduced into the pericardial space under fluoroscopic imaging.5

The thermal energy from the ablation procedure results in local myocardial cell necrosis extending transmurally to involve the pericardial layers.6 Consequently, a local and systemic inflammatory response sets in which clinically translates into pericardial chest pain, and/or fever, diffuse ST-segment elevation on ECG, pericardial friction rubs or pericardial effusion. Laboratory investigations can reveal elevated inflammatory markers like C-reactive protein (CRP) and troponin elevation in cases of concomitant myocardial injury.7 Patients can also present with clinical features of constrictive pericarditis like significant dyspnea, elevated jugular venous pressure, and ankle edema.

Multimodality Imaging

Multimodality imaging plays a crucial role in diagnosis and management of pericardial diseases including post ablation pericarditis. It is often performed to confirm a clinical suspicion and should follow a comprehensive history and physical examination, laboratory investigations, and ECG. Transthoracic echocardiography (TTE) is usually the first imaging modality performed. The cardinal findings of acute pericarditis include the presence of pericardial effusion with or without tamponade, increased pericardial brightness and pericardial thickening.8 When patients present with features of constrictive physiology, the TTE findings include inferior vena cava plethora (a sign of increased right atrial pressure), moderate biatrial enlargement, sudden restriction of ventricular diastolic filling, early diastolic septal bounce, or respirophasic interventricular septal shift. On computed tomography (CT) scan, noncalcified pericardial thickening with effusion suggests acute pericarditis. Additionally, CT scan is an excellent modality for pericardial thickness evaluation in cases where patients present with constrictive pericarditis after ablation. It is also very accurate for detection of pericardial calcification.8 Cardiac magnetic resonance (CMR) is another integral modality which compliments the TTE and CT findings. It provides an accurate anatomic delineation from adjacent structures. The important features of acute pericardial inflammation after ablation on CMR are enhancement of the thickened pericardium or late gadolinium enhancement. Considerable pericardial tissue signal on T2 weighted images (T2WI) corresponding to neovascularization, edema and/or granulation tissue. Features of constriction include the changes like TTE – abrupt halt of diastolic filling, septal bounce, respirophasic shift of interventricular septum, and pericardial thickening. CMR images of different cases of acute pericarditis after ablation procedure for arrhythmias like AF, premature ventricular contraction (PVC) and VT are depicted in Figures 1, 2 and 3, respectively.

Figure 1

Figure 1

Figure 2

Figure 2

Figure 3

Figure 3

Literature on post ablation pericarditis is sporadic. Nakhla et al., in their single center analysis, demonstrated that 10.2% of patients had suspected acute pericarditis after catheter ablation for AF. Of note, the study definition of pericarditis was post ablation pericardial chest pain treated with anti-inflammatories. Younger patients, more likely presenting with paroxysmal AF, appeared to be most at risk.9 Using a nationwide database, Darmoch et al. showed that 0.8% of patients developed acute pericarditis who underwent AF ablation. The trends of acute pericarditis after AF ablation showed fluctuations but more inclined towards reduction. Interestingly, multivariate analysis reflected female sex and obesity were associated with higher risk.10 In another retrospective study conducted by Mugnai et al., 4% of patients developed acute pericarditis after cryoballoon ablation of AF. It was depicted to be associated with the number of cryoapplications and total freezing time. There was no difference witnessed in AF recurrence rates between patients who developed pericarditis after cryoballoon ablation versus those who did not.7 In a multi-center study conducted by Sacher et al., 121 out of 913 VT ablations underwent epicardial ablation. Acute intrapericardial bleeding was witnessed in 4.5% cases and delayed (>48 hours) complications like major pericardial inflammation and cardiac tamponade were seen in 0.6% and 0.6% cases, respectively.11 Bella et al. reported that 3.7% cases developed cardiac tamponade with combined endo-epicardial VT ablation.12 Additionally, Tung et al. demonstrated a 6.7% rate of pericardial bleeding among 95 patients who underwent epicardial ablation for VT.13 Some case reports have also been established showing the development of acute as well as constrictive pericarditis after ablation for various arrhythmias like AF, PVC, VT, Wolff-Parkinson-White syndrome, and atrioventricular nodal reentrant tachycardia.6,14-17


The management of post ablation pericarditis is usually similar to any other case of pericarditis. The goal of treatment is to minimize the pericardial inflammation. There are many treatment options available like nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, steroids and steroid sparing agents like azathioprine, methotrexate, and intravenous immunoglobulins.18 NSAIDs remain the mainstay of management for acute pericarditis.19 Oral ibuprofen 600 to 800 mg every 8 hours or oral indomethacin 50 mg every 8 hours are the recommended initial choices. Aspirin 2-4 g/day is recommended in patients with concomitant cardiovascular comorbidities.20 Colchicine is another first line agent used concomitantly with NSAIDs with a recommended dose of 0.6 mg twice daily.2,21 Corticosteroids like prednisone are indicated when the patient is either intolerant or there is any contraindication or incomplete or no symptom resolution with NSAIDs/colchicine.2 Low doses of prednisone (0.2-0.5 mg/kg/day) are recommended with a slow taper which, in turn, should be introduced only with complete resolution of symptoms and normal CRP levels.22 Immunosuppressive medications like azathioprine, methotrexate, and hydroxychloroquine can also be used but more commonly in cases of recurrent pericarditis after ablation. Interleukin-1 blockers, like anakinra and rilonacept have gained momentum recently by showing excellent efficacy. Anakinra has shown to reduce recurrence of pericarditis in colchicine-resistant and steroid dependent pericarditis.23 Recently, RHAPSODY trial showed an outstanding result of rilonacept in treating recurrent pericarditis which eventually got US Food and Drug Administration approval.24 It can also be used as a steroid sparing monotherapy and helps taper off all the other anti-inflammatory agents. On failure of optimal medical management, patients can also be considered for surgical pericardiectomy as a last resort.2

In conclusion, post ablation pericarditis has been observed in clinical settings but is poorly reported. Patients should be meticulously monitored after ablation procedure as early management of acute pericarditis is crucial to prevent complications like recurrence and constriction.


  1. Li W, Sun J, Yu Y, et al. Clinical features of post cardiac injury syndrome following catheter ablation of arrhythmias: systematic review and additional cases. Heart Lung Circ 2019;28:1689–96.
  2. Adler Y, Charron P, Imazio M, et al. 2015 ESC guidelines for the diagnosis and management of pericardial diseases. Eur Heart J 2015;36:2921–64.
  3. Link MS, Haïssaguerre M, Natale A. Ablation of atrial fibrillation. Circulation 2016;134:339–52.
  4. Packer DL, Kowal RC, Wheelan KR, et al. Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: first results of the North American Arctic Front (STOP AF) pivotal trial. J Am Coll Cardiol 2013;61:1713–23.
  5. Stevenson WG, Soejima K. Catheter ablation for ventricular tachycardia. Circulation 2007;115:2750–60.
  6. Zheng MF, Wang Z, Bao ZY. Myocardial injury and pericarditis after combined left atrial and coronary sinus ablation in Wolff-Parkinson-White syndrome: a case report. BMC Cardiovasc Disord 2020;20:18.
  7. Mugnai G, de Asmundis C, Iacopino S, et al. Acute pericarditis following second-generation cryoballoon ablation for atrial fibrillation. J Interv Card Electrophysiol 2018;51:279–84.
  8. Klein AL, Abbara S, Agler DA, et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease: endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr 2013;26:965-1012.e15.
  9. Nakhla S, Mentias A, Rymer C, et al. Acute pericarditis after atrial fibrillation ablation: incidence, characteristics, and risk factors. Heart Rhythm O2 2022;3:248–51.
  10. Darmoch F, Alraies MC, Al-khadra Y, et al. National trends of acute pericarditis post-atrial fibrillation ablation. Int J Clin Pract 2020;74:e13434.
  11. Sacher F, Roberts-Thomson K, Maury P, et al. Epicardial ventricular tachycardia ablation a multicenter safety study. J Am Coll Cardiol 2010;55:2366–72.
  12. Della Bella P, Brugada J, Zeppenfeld K, et al. Epicardial ablation for ventricular tachycardia: a European multicenter study. Circ Arrhythm Electrophysiol 2011;4:653–59.
  13. Tung R, Michowitz Y, Yu R, et al. Epicardial ablation of ventricular tachycardia: an institutional experience of safety and efficacy. Heart Rhythm 2013;10:490–98.
  14. Davtyan K V, Topchyan AH, Mershina EA, Sinitsyn VE. Regional pericarditis following uncomplicated catheter ablation procedure: a case report. Eur Heart J Case Rep 2022;Jan:[Epub ahead of print].
  15. Javaheri A, Glassberg HL, Acker MA, Callans DJ, Goldberg LR. Constrictive pericarditis presenting as a late complication of epicardial ventricular tachycardia ablation. Circ Heart Fail 2012;5:e22–3.
  16. Ahsan SY, Moon JC, Hayward MP, Chow AWC, Lambiase PD. Constrictive pericarditis after catheter ablation for atrial fibrillation. Circulation 2008;118:e834-5.
  17. Wenzl FA, Manninger M, Wunsch S, Scherr D, Bisping EH. Post-cardiac injury syndrome triggered by radiofrequency ablation for AVNRT. BMC Cardiovasc Disord 2021;21:10–3.
  18. Kumar S, Khubber S, Reyaldeen R, et al. Advances in imaging and targeted therapies for recurrent pericarditis: a review. JAMA Cardiol 2022;7:975-85.
  19. Chiabrando JG, Bonaventura A, Vecchié A, et al. Management of acute and recurrent pericarditis: JACC State-of-the-Art Review. J Am Coll Cardiol 2020;75:76–92.
  20. Imazio M, Brucato A, Mayosi BM, et al. Medical therapy of pericardial diseases: part I: idiopathic and infectious pericarditis. J Cardiovasc Med 2010;11:712–22.
  21. Imazio M, Belli R, Brucato A, et al. Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trial. Lancet 2014;383:2232–37.
  22. Imazio M, Brucato A, Cumetti D, et al. Corticosteroids for recurrent pericarditis: high versus low doses: a nonrandomized observation. Circulation 2008;118:667–71.
  23. Brucato A, Imazio M, Gattorno M, et al. Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence: the AIRTRIP randomized clinical trial. JAMA 2016;316:1906–12.
  24. Klein AL, Imazio M, Cremer P, et al. Phase 3 trial of interleukin-1 trap rilonacept in recurrent pericarditis. N Engl J Med 2021;384:31–41.

Clinical Topics: Arrhythmias and Clinical EP, Cardiac Surgery, Congenital Heart Disease and Pediatric Cardiology, Diabetes and Cardiometabolic Disease, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Noninvasive Imaging, Pericardial Disease, EP Basic Science, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Cardiac Surgery and Arrhythmias, Cardiac Surgery and CHD and Pediatrics, Cardiac Surgery and Heart Failure, Congenital Heart Disease, CHD and Pediatrics and Arrhythmias, CHD and Pediatrics and Imaging, CHD and Pediatrics and Interventions, CHD and Pediatrics and Prevention, CHD and Pediatrics and Quality Improvement, Novel Agents, Statins, Heart Failure and Cardiac Biomarkers, Interventions and Imaging, Interventions and Structural Heart Disease, Computed Tomography, Echocardiography/Ultrasound, Nuclear Imaging

Keywords: Retrospective Studies, Pericardial Effusion, Azathioprine, Aleurites, C-Reactive Protein, Contrast Media, Gadolinium, Hydroxychloroquine, Ibuprofen, Immunoglobulins, Intravenous, Interleukin 1 Receptor Antagonist Protein, Methotrexate, Polyvinyl Chloride, Prednisone, Atrial Fibrillation, Pulmonary Veins, Cryosurgery, Pericarditis, Constrictive, Cardiac Tamponade, Atrial Pressure, Constriction, Depression, Freezing, Friction, Pericardiectomy, Tachycardia, Atrioventricular Nodal Reentry, United States Food and Drug Administration, Vena Cava, Inferior, Ventricular Premature Complexes, Wolff-Parkinson-White Syndrome, Pericarditis, Catheter Ablation, Pericardium, Electrocardiography, Tachycardia, Ventricular, Echocardiography, Anti-Inflammatory Agents, Tomography, X-Ray Computed, Obesity, Systemic Inflammatory Response Syndrome, Multivariate Analysis, Physical Examination, Granulation Tissue, Magnetic Resonance Spectroscopy, Contraindications, Venous Pressure, Adrenal Cortex Hormones, Inflammation, Interleukin-1, Indomethacin, Chest Pain, Colchicine, Tomography, Catheters, Troponin, Dyspnea, Necrosis, Aspirin, Anti-Inflammatory Agents, Non-Steroidal, Edema

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