This issue brings together a set of stories united by a central theme familiar to every cardiologist: how high‑quality evidence becomes high‑value care. From prevention in childhood to advanced interventions for complex disease, each story in these pages reflects a different point along the continuum of heart health – yet all focus on turning research into meaningful, practical action.

Our cover story about renal denervation for resistant hypertension illustrates the long arc of innovation. After years of careful evaluation, iterative refinement and scientific debate, it now stands on firm clinical footing with durable efficacy, a strong safety record and guideline inclusion. Its journey highlights how persistence and rigorous science can ultimately reshape practice.

Evidence shows that the stage for developing heart disease is often set early in life. It is time for prevention to move to a new frontier – helping children, families and communities build heart‑healthy habits from the very beginning. Our feature explores this strategy, the foundation of the Fuster Prevention Forum, which will provide structured training and evidence‑based educational materials with proven success in primordial prevention to the first cohort of "Fuster Fellows."

Speaking of earlier in life, this month's Number Check spotlights the newly released ACC/AHA Guideline on the Management of Dyslipidemia, offering a concise look at key messages from this comprehensive "one‑stop‑shop" document. One of the top takeaways – early screening starting as early as 9 years old.

Also in this issue, dive into some of the new science from ACC.26 in JACC in a Flash and in Prioritizing Health and look to next month's issue for even more key takeaways from the meeting.

For patients with tricuspid regurgitation, transcatheter valve intervention has emerged as a promising treatment option for select patients. But what do the limited data say for whom and when? Turn to page 28 to learn more in Cutting-Edge Structural Interventions. Plus, don't miss features highlighting the efforts of ACC Chapters over the last year to advance the ACC's Mission and read how ACC Accreditation Services helped one health system achieve quality improvement and meet national benchmarks across eight sites.

We hope this issue informs your practice and sparks new conversations within your teams and institutions. As always, we welcome your thoughts at CardiologyEditor@acc.org.

Clinical Topics: Diabetes and Cardiometabolic Disease, Dyslipidemia, Prevention, Hypertension

Keywords: Cardiology Magazine, ACC Publications, CM-Apr-2026, Tricuspid Valve Insufficiency, Dyslipidemias, Primary Prevention, Habits, Hypertension, Denervation