Functional Testing Underlying Revascularization - FUTURE

Contribution To Literature:

The FUTURE trial was terminated early, but showed similar event rates for FFR-guided versus angiography-guided revascularization.


The goal of the trial was to evaluate fractional flow reserve (FFR)-guided revascularization compared with angiography-guided revascularization among patients with ≥2 coronary stenoses (≥50%).

Study Design

  • Randomized
  • Parallel

Patients with multivessel coronary artery disease were randomized to FFR-guided revascularization versus angiography-guided revascularization.

Inclusion criteria:

  • Stable patients with at least 2 coronary stenoses (≥50%).
  • Total number of enrollees: 864
  • Duration of follow-up: 1 year
  • Percentage with diabetes: 32%

Other salient features/characteristics:

  • SYNTAX score: mean 18.5

Principal Findings:

The primary outcome, all-cause death, myocardial infarction, or stroke, occurred in 14.4% of the FFR group compared with 14.6% of the angiography group (p = 0.94).

Adverse events were higher in the FFR group when SYNTAX score was ≥32.


Among patients with multivessel coronary disease, FFR-guided revascularization resulted in similar outcomes compared with angiography-guided revascularization. Unfortunately, this trial was terminated early due to an unexplained increase in mortality in the FFR group.


Presented by Dr. Gilles Rioufo at the European Society of Cardiology Congress, Munich, Germany, August 25, 2018.

Keywords: ESC Congress, ESC18, Angina Pectoris, Coronary Artery Disease, Coronary Stenosis, Fractional Flow Reserve, Myocardial, Myocardial Infarction, Myocardial Ischemia, Myocardial Revascularization, Stroke

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