Early vs. Delayed Lead Extraction in Patients With Infected CIEDs

Quick Takes

  • Patients with infected cardiovascular implantable electronic devices (CIED) have increased morbidity and mortality.
  • The rate of persistent and/or recurrent infection is high, and thus complete device and lead removal is recommended when infection is confirmed.
  • This study shows the benefit of early (<7 days) device and lead extraction in patients with bacteremia as well as patients with isolated pocket infection.

Study Questions:

What is the effect of early versus delayed lead extraction on in-hospital morbidity and long-term mortality in patients presenting with infected cardiovascular implantable electronic devices (CIEDs)?

Methods:

The cases of 233 consecutive CIED extractions at a single medical center from 2006 to 2019 were reviewed. Patients were separated into two groups, those with: 1) bacteremia, or 2) isolated pocket infection. Within the two groups, patients were further divided based on time from hospital admission to CIED extraction using 7 days as the cutoff between “early” and “delayed.” In-hospital morbidity, 1-year mortality, and major comorbidities were compared.

Results:

Of the 233 total patients, 127 patients had bacteremia and 106 patients had pocket infection. In the bacteremia group, 74% underwent delayed extraction (mean 15.2 days); the majority were transfers from outside hospitals and presented at a later time in their inpatient course; delayed extraction was also associated with septic shock (odds ratio [OR], 5.39; 95% confidence interval [CI], 1.23-23.67; p = 0.026), acute kidney injury (OR, 5.61; 95% CI, 2.15-14.63; p < 0.001), respiratory failure (OR, 5.52; 95% CI, 1.25-24.41; p = 0.024), and decompensated heart failure (OR, 3.32; 95% CI, 1.10-10.05; p = 0.033); 11 died among the delayed extraction group and none in the early group with septic shock as most common cause of death (n = 8). Isolated pocket infection patients were also more likely to be transfers from outside hospitals at a later time after initial presentation; 15% had delayed extraction (mean 10.7 days) with higher rates of acute kidney injury (OR, 3.45; 95% CI, 1.11-10.77; p = 0.033) and respiratory failure (OR, 10.29; 95% CI, 1.26-83.93; p = 0.030); one patient died of cardiac arrest, and no patients died in the early extraction group. Delayed extraction in both bacteremia and pocket infection groups was significantly associated with increased 1-year mortality. Overall complication rate (3%) was similar between groups.

Conclusions:

Delayed infected CIED extraction is associated with worse in-hospital morbidity and 1-year mortality outcomes. Early detection and prompt device and lead extraction are essential to the management of CIED patients with bacteremia and/or isolated pocket infection.

Perspective:

This study highlights the importance of prompt diagnosis and management of infection and early referral for device and lead extraction. Limitations include the retrospective design, single-center experience, nonuniform treatment decisions by primary teams, and limited follow-up records for patients transferred back to referring hospitals.

Delayed intervention has been consistently associated with worse outcomes. Confirmation of bacteremia delays diagnosis compared to the visual presentation of pocket infection. Arrangements for transfer to a tertiary center with a multidisciplinary lead extraction team can further delay treatment. Action plans are needed between local hospitals and referral centers to expedite CIED extraction when appropriate.

Clinical Topics: Arrhythmias and Clinical EP, Diabetes and Cardiometabolic Disease, Heart Failure and Cardiomyopathies, Prevention, Implantable Devices, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Acute Heart Failure

Keywords: Acute Kidney Injury, Arrhythmias, Cardiac, Bacteremia, Comorbidity, Defibrillators, Implantable, Heart Arrest, Heart Failure, Infections, Pacemaker, Artificial, Respiratory Insufficiency, Secondary Prevention, Shock, Septic


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