Atrial Fibrillation Symptom Under-Recognition and Catheter Ablation
Quick Takes
- Under-recognition of atrial fibrillation symptom burden is common in clinical practice and is associated with less aggressive treatment for rhythm control.
- Symptom under-recognition by physicians was associated with nonuse of catheter ablation (odds ratio, 0.41; 95% confidence interval, 0.28-0.60).
Study Questions:
Is symptom under-recognition by physicians associated with lower rates of patients undergoing catheter ablation for atrial fibrillation (AF)?
Methods:
The authors analyzed the multicenter KiCS-AF (Keio interhospital Cardiovascular Studies–Atrial Fibrillation) registry, where all patients underwent symptom burden assessment of the Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) questionnaire. Under-recognition of symptom burden was defined as no subjective complaints checked by physicians despite self-reported AFEQT scores ≤80.
Results:
In a cohort of 3,276 patients in the registry, 1,173 patients had AFEQT score ≤80 denoting symptomatic status. Mean age was 68 years and 61% of the patients were men. Among the 1,173 patients, 459 underwent catheter ablation, and these patients had lower overall AFEQT scores compared with the nonablation group. At the 1-year follow-up, greater improvement in the AFEQT scores was noted in the ablation group. Importantly, 306 (28%) patients met the criteria for symptom under-recognition by physicians, which was associated with nonuse of catheter ablation during follow-up (odds ratio, 0.41; 95% confidence interval, 0.28-0.60; p < 0.001).
Conclusions:
The authors concluded that under-recognition of AF symptoms by physicians was common and associated with less use of catheter ablation.
Perspective:
Catheter ablation has emerged as an important intervention for patients with atrial fibrillation, both after a failure of antiarrhythmic drug(s) and as a first-line approach. Given that there is relatively limited evidence of decreased mortality and morbidity with rhythm-control strategy, interventions aiming to restore and maintain sinus rhythm, including catheter ablation, have been offered to patients who, physicians believe, have enough symptoms to warrant an intervention. The current study shows the limitations of physician interview in the assessment of AF symptom severity and impact on quality of life. Almost a third of patients who reported significant symptoms through the AFEQT survey were thought to be asymptomatic by their physicians. If these findings are confirmed, future studies should address the utility of validated questionnaires to help in patient-centered decision making regarding rhythm control, and how such measures could potentially facilitate the treatment of patients and improve clinical outcomes in patients with AF.
Clinical Topics: Anticoagulation Management, Arrhythmias and Clinical EP, Prevention, Anticoagulation Management and Atrial Fibrillation, Implantable Devices, EP Basic Science, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias
Keywords: Anti-Arrhythmia Agents, Anticoagulants, Arrhythmias, Cardiac, Atrial Fibrillation, Catheter Ablation, Patient-Centered Care, Quality of Life, Secondary Prevention, Symptom Assessment
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