Patients with uncontrolled hypertension demonstrated a substantial reduction in office and ambulatory systolic blood pressure (SBP) following renal denervation with a favorable safety profile, according to results from the Global SYMPLICITY Registry study presented on Aug. 30 as part of ESC Congress 2014.

Additional Resources ESC Congress 2014 Meeting Coverage Global SYMPLICITY Registry: Renal Artery Denervation in Uncontrolled HTN Presentation Slides

The Global SYMPICITY Registry contains approximately 5,000 "real-world" patients from 245 sites in 37 countries participating in the Global SYMPLICITY Registry. For this particular study, investigators looked at 1,000 registry patients following renal denervation at three months, six months and 12 months.

Overall, study investigators saw significant improvement in office SBP in patients following renal denervation over the course of a year, with nearly 60 percent of patients having an in office SBP of 159 mm Hg or less by 12 months. Of those patients, approximately 20 percent had in-office SBP of <140 mm Hg. Moving forward, it’s important to note that these provocative data are observational and ideally ought to be confirmed in a future blinded, sham controlled trial, said Deepak L. Bhatt, MD, MPH, FACC, executive director of Interventional Cardiovascular Programs at Brigham and Women's Hospital and professor of medicine at Harvard Medical School. View slides.

Keywords: Registries, Denervation, Schools, Medical, Kidney, Hypertension, Systole

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