Most Accessed JACC Studies of 2014
Troponin-T, PCSK9-Inhibitors and Surgery For Leaky Heart Valves Among Top Studies

Among the top accessed research studies in the Journal of the American College of Cardiology (JACC) in 2014 include a blood test to rule out myocardial infarction, an advisory about guidelines for preventing high blood pressure, cutting edge research on a new class of cholesterol drugs, and a study that found benefits in early surgery for mitral regurgitation.

Here is the full list of the most accessed papers from the family of JACC journals in 2014:




  • Exercise Testing in Asymptomatic Severe Aortic Stenosis
    • This study found that in asymptomatic patients with severe aortic stenosis, exercise stress test and exercise stress echocardiography may provide incremental clinical and prognostic value, in addition to physical examination and resting echocardiography. Exercise stress test may identify resting asymptomatic patients who develop exercise abnormalities and in whom surgery may be recommended according to current guidelines. Exercise stress echocardiography may further unmask a subset of asymptomatic patients who are at high risk of reduced cardiac event free survival. In these patients, early surgery may be beneficial, whereas regular follow-up seems more appropriate in patients without echocardiographic abnormalities during exercise.
  • Redefining Diastolic Dysfunction Grading: Combination of E/A =0.75 and Deceleration Time
    • The new DD grade is frequently observed and has a prognosis similar to that of the pseudonormal group but significantly worse than that of the impaired relaxation group. However, LA booster function was maintained at the expense of LA volume enlargement. Thus, the new grade should be a distinct entity for routine diastolic dysfunction grading.


Clinical Topics: Anticoagulation Management, Arrhythmias and Clinical EP, Dyslipidemia, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Noninvasive Imaging, Prevention, Pulmonary Hypertension and Venous Thromboembolism, Valvular Heart Disease, Atherosclerotic Disease (CAD/PAD), Implantable Devices, SCD/Ventricular Arrhythmias, Homozygous Familial Hypercholesterolemia, Lipid Metabolism, Nonstatins, Statins, Acute Heart Failure, Heart Failure and Cardiac Biomarkers, Pulmonary Hypertension, Interventions and Coronary Artery Disease, Interventions and Imaging, Interventions and Structural Heart Disease, Echocardiography/Ultrasound, Hypertension

Keywords: Acetylcholine, Acute Kidney Injury, Adenosine, Algorithms, American Heart Association, Angina Pectoris, Anticoagulants, Aortic Valve Stenosis, Aspirin, Azetidines, Biological Markers, Centers for Disease Control and Prevention (U.S.), Cholesterol, Coronary Artery Disease, Coronary Artery Disease, Deceleration, Defibrillators, Diabetes Mellitus, Diabetes Mellitus, Diagnostic Tests, Routine, Disease-Free Survival, Echocardiography, Stress, Emergency Service, Hospital, Endothelium, Exercise Test, Exercise Test, Fluorobenzenes, Health Personnel, Health Status, Heart Failure, Heart Valves, Hematologic Tests, Hypercholesterolemia, Hypertension, Hypertension, Pulmonary, Incidence, Lipoproteins, LDL, Metoprolol, Myocardial Infarction, Percutaneous Coronary Intervention, Pharmaceutical Preparations, Prevalence, Primary Prevention, Pyrimidines, Renal Insufficiency, Risk Factors, Stents, Stroke, Sulfonamides, Thrombosis, Troponin T, Watchful Waiting

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