Currently no approved therapies exist to target obesity-related heart failure with preserved ejection fraction, a condition increasing in prevalence and associated with high symptom burden. In this interview, Mikhail Kosiborod MD, and Alison L. Bailey MD, FACC, discuss ESC Hot Line: STEP HFpEF: once-weekly semaglutide in people with HFpEF and obesity.

Related References:

1. Kosiborod M, Abildstrøm S, Borlaug B, et al. Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype. J Am Coll Cardiol HF. 2023 Aug, 11 (8_Part_1) 1000–1010. https://doi.org/10.1016/j.jchf.2023.05.010
2. Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, Hovingh GK, Kitzman DW, Lindegaard ML, Møller DV, Shah SJ, Treppendahl MB, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Núñez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, Petrie MC; STEP-HFpEF Trial Committees and Investigators. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2023 Sep 21;389(12):1069-1084. doi: 10.1056/NEJMoa2306963. Epub 2023 Aug 25. PMID: 37622681.