Intimal Hyperplasia Inhibition with Beta In-stent Trial - INHIBIT
Use of beta-radiation brachytherapy with a P-32 source (Nucleon afterloader) for treatment of diffuse in-stent restenosis
Beta-radiation brachytherapy with a P-32 source can reduce MACE and restenosis after treatment of in-stent restenosis
Patients Enrolled: 332
Mean Follow Up: 9 months
Single native vessel in-stent restenosis Reference vessel diameter 2.4-3.7 mm Lesion length <45 mm
Composite safety endpoint of death, Q wave MI and TLR Angiographic binary restenosis
P-32 beta emitter versus placebo delivered through a centering catheter via an automatic afterloader after PTCA for in-stent restenosis
There was a 56% reduction (14% irradiated versus 31% control) in composite endpoint of death, Q wave myocardial infarction, and target lesion resvascularization(p=0.0002) among patients treated with P-32 beta irradiation. There was a 50% reduction (26% irradiated versus 52% control) in the angiographic binary restenosis rate (p=0.0003)among patients treated with P-32 beta irradiation.
Beta-radiation with the P-32 source is associated with a reduction in restenosis and MACE after treatment of in-stent restenosis.
Circulation 2000;102:e9046. Lancet 2002 Feb 16;359(9306):551-7
Keywords: Myocardial Infarction, Beta Particles, Coronary Restenosis, Brachytherapy, Stents
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