Generation 100 - GEN100
Contribution To Literature:
The Generation 100 study failed to show that supervised exercise training prevents cardiovascular events.
The goal of the trial was to evaluate high-intensity interval training compared with moderate-intensity continuous training among healthy, fit elderly individuals.
Healthy and fit elderly individuals were randomized to high-intensity interval training (n = 400) versus moderate-intensity continuous training (n = 387) versus control (n = 780).
Exercise was supervised in the high-intensity interval training and moderate-intensity continuous training group. In the high-intensity interval training group, the target heart rate was ~90% of peak heart rate. In the moderate-intensity continuous training group, the target heart rate was ~70% of peak heart rate.
Participants in the control group were asked to participate in 30 minutes of moderate-intensity exercise most days per week.
- Total number of enrollees: 1,567
- Duration of follow-up: 5 years
- Mean patient age: 73 years
- Percentage female: 50%
- Healthy and fit elderly individuals (aged 70-77 years)
- Live in Trondheim, Norway
Continuous cardiovascular risk score was not significantly lower (-0.19, 99% confidence interval [CI] -0.46 to 0.07) and peak oxygen uptake (peak VO2) was not significantly higher (0.39 ml/kg/min, 99% CI -0.22 to 1.00) for combined exercise training versus control.
Among fit elderly individuals, supervised exercise training failed to improve a continuous cardiovascular risk score or improve peak VO2. Enrollment of healthy, fit individuals may have resulted in selection bias and limited the ability to detect a difference between groups.
Letnes JM, Berglund I, Johnson KE, et al. Effect of 5 years of exercise training on the cardiovascular risk profile of older adults: the Generation 100 randomized trial. Eur Heart J 2021;Nov 8:[Epub ahead of print].
Keywords: Cardiorespiratory Fitness, Exercise, Geriatrics, Health Status, Heart Disease Risk Factors, Heart Rate, High-Intensity Interval Training, Primary Prevention, Risk Factors
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