Results:

A total of 242 adolescents were included in this study, of which 161 participants underwent a Roux-en-Y gastric bypass and 67 participants underwent a sleeve gastrectomy. The mean age at baseline was 17 ± 1.6 years, and the mean body mass index was 53 kg/m². The majority of the cohort was female (75%) and white (72%). At 3 years after the procedure, the mean weight had decreased by 27% (95% confidence interval [CI], 25-29) in the total cohort. For those who underwent gastric bypass, mean weight decreased by 28% (95% CI, 25-30), and for those who underwent sleeve gastrectomy, mean weight decreased by 26% (95% CI, 22-30). Significant improvements in metabolic conditions were observed including remission of type 2 diabetes in 95% of participants who were diabetic at baseline (95% CI, 85-100) and remission of prediabetes in 76% of participants (95% CI, 56-97). Significant improvements were also observed in kidney function, blood pressure, and dyslipidemia. Weight-related quality of life also improved significantly. In terms of adverse effects, at 3 years, hypoferritinemia was found in 57% (95% CI, 50-65) of the participants, and 13% (95% CI, 9-18) of the participants had undergone one or more additional intra-abdominal procedures.