VTE Prevention for Patients Undergoing Major Orthopedic Surgery

A 72-year-old man with a history of obesity, stable coronary artery disease, and known Factor V Leiden mutation presents for pre-operative cardiovascular assessment prior to a planned right hip arthroplasty surgery. His current medications include aspirin 81mg daily, metoprolol 50mg twice a day, atorvastatin 40mg daily, and lisinopril 5mg daily. He has no known prior history of venous thromboembolism (VTE) or cancer. His most recent renal function and liver function laboratory values were normal.

Which of the following regimens would be appropriate for prevention of VTE following his orthopedic surgery?

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