Chicago Stroke Study - Chicago Stroke Study

Description:

Assessment of adiposity and truncal obesity as independent risk factors for stroke using the Chicago Stroke Study cohort

Hypothesis:

The purpose of this study was to test the hypothesis that overall and truncal adiposity increase the risk of stroke independent of their association with cardiovascular disease risk factors and other preexisting illnesses

Study Design

Study Design:

Mean Patient Age: 65-74

Drug/Procedures Used:

Analyses were conducted of longitudinal data from a poor, biracial cohort of noninstitutionalized adults 65 to 74 years of age who participated in the Chicago Stroke Study from 1965 to 1970.

Principal Findings:

Ponderal index (cm/kg1/3) and chest skinfold were significantly associated with systolic and diastolic blood pressure, serum cholesterol and triglycerides, plasma glucose, and smoking. Ponderal index was also associated with diabetes and risk of stroke. After potential confounders were controlled, the following variables showed significant independent associations with risk of stroke: Black race, female gender, and age 70+; hypertensive heart disease; and diabetes. Neither adiposity variable was associated with risk of stroke

Interpretation:

Excess adiposity may not be an independent risk factor for stroke, but it may be indirectly related to the risk of stroke by virtue of its association with hypertension, diabetes, and other cardiovascular disease risk factors.

References:

American Journal of Public Health. 84(1):14-9, 1994 Jan.

Clinical Topics: Diabetes and Cardiometabolic Disease, Dyslipidemia, Prevention, Lipid Metabolism, Nonstatins, Triglycerides, Hypertension, Smoking

Keywords: Obesity, Abdominal, Stroke, Blood Pressure, Risk Factors, Smoking, Glucose, Heart Diseases, Cholesterol, Adiposity, Preexisting Condition Coverage, Triglycerides, Diabetes Mellitus, Hypertension


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