Stent Restenosis Study III - STRESS III
Stenting vs. PTCA for angiographic restenosis in CAD.
To assess the incidence of restenosis in patients undergoing stent implantation with high pressure (> 16 atm) post-dilatation.
Patients Screened: Not given
Patients Enrolled: 250
Mean Follow Up: 1 year
De novo native coronary artery lesions
Vessel size 3.0-4.0mm
Lesion length < 15mm
Binary restenosis at 6 months
Acute and subacute vessel closure
The greater acute procedural gain observed with high pressure stent deployment was offset by significantly greater late loss, resulting in no benefit on 6-month luminal diameter or restenosis.
High-pressure deployment and antiplatelet therapy was associated with a 37% reduction in major adverse cardiac events (death, MI, CABG, or target lesion revascularization) at one year compared to the stent arm of the STRESS I trial (12.9% vs 20.5%, p=0.03).
Although high pressure deployment did not result in improved angiographic outcomes compared to the stent arm of STRESS I, refinements in devices, technique, and pharmacotherapy have significantly improved clinical outcomes.
1. Circulation 98(Suppl I):I-823. Preliminary results
Keywords: Coronary Artery Disease, Dilatation, Stents
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