Results:

A total of 100 patients were screened and 33 either withdrew, refused, or there were technical issues with the sleep study or they were lost to follow-up. Endpoint analysis was performed on 67 patients at an average of 4.5 years (range 3.2-6.1 years). Average age was 58 ± 8 years, and 75% were men. Moderate to severe OSA (apnea-hypopnea index >15) was present in 56%. Differences among OSA patients compared to no OSA included: older age, lower ejection fraction, greater use of statin, higher waist circumference, but these did not reach statistical difference. Only one patient diagnosed with OSA was treated with positive airway therapy during the trial, given lack of Public Health System providing continuous positive airway pressure for OSA. Since this patient had low adherence to treatment, he remained in the final analysis. No difference in short-term outcomes was observed. Long-term events measured on average 4.5 years were more common in patients with than without OSA. The higher rates of new revascularization, angina, and atrial fibrillation were primarily driven by the rates of revascularization (no OSA 3%; OSA 22%; p = 0.035). In a multivariate analysis, OSA was independently associated with repeat revascularization, angina, and atrial fibrillation following bypass surgery.