Methods:

The investigators performed a meta-analysis of randomized controlled trials (RCTs) comparing complete MV-PCI with noncomplete MV-PCI in STEMI and MV disease. Complete MV-PCI was defined as revascularization to noninfarct-related artery lesions during index procedure, noncomplete MV-PCI–encompassed culprit-only revascularization, and staged approaches. Multiple databases and congress proceedings from major cardiovascular societies’ meetings were screened for relevant studies. The primary endpoint was the composite of major adverse cardiac events (MACE) typically defined as death, recurrent MI, and repeat revascularization. Secondary endpoints were cardiovascular mortality, recurrent MI, and repeat revascularization. Outcomes were analyzed at longest available follow-up, with differences accounted for with adjusted models by person-years.