Omega-3 Supplementation and CVD Prevention

Siscovick DS, Barringer TA, Fretts AM, et al.
Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association. Circulation 2017;Mar 13:[Epub ahead of print].

The following are key points to remember from this American Heart Association Science Advisory on omega-3 polyunsaturated fatty acid (PUFA) supplementation and the prevention of cardiovascular disease:

  1. Among patients with coronary heart disease (CHD), treatment with PUFA supplementation to reduce CHD-related mortality (in particular ischemic-mediated sudden cardiac death) is reasonable.
  2. For patients with heart failure with reduced left ventricular function, a large randomized controlled trial (RCT) observed benefit (reduced hospitalization and improved survival) with omega-3 PUFA supplementation.
  3. For diabetic and prediabetic patients, there is no significant evidence to support omega-3 PUFA supplementation for the prevention of CHD. However, an ongoing RCT will address primary prevention with omega-3 supplementation in diabetic patients.
  4. Among patients with a history of stroke, there are no published RCTs to support omega-3 supplementation. There is also no proven benefit for primary prevention of stroke.
  5. There is no evidence to support the use of omega-3 PUFA supplementation for primary prevention of atrial fibrillation. Data from multiple RCTs do not support the use of omega-3 supplementation to prevent recurrent atrial fibrillation.

Clinical Topics: Arrhythmias and Clinical EP, Dyslipidemia, Heart Failure and Cardiomyopathies, Prevention, Atherosclerotic Disease (CAD/PAD), SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Lipid Metabolism, Nonstatins, Acute Heart Failure

Keywords: Atrial Fibrillation, Cardiovascular Diseases, Coronary Artery Disease, Death, Sudden, Cardiac, Diabetes Mellitus, Fish Oils, Fatty Acids, Omega-3, Heart Failure, Ischemia, Primary Prevention, Secondary Prevention, Stroke, Ventricular Function, Left

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