Top Journal Scans

Kim A. Eagle, MD, MACC
Editor-in-Chief, ACC.org

As we saw in 2020, 2021 was a year where scientific information about COVID-19, its prevention, diagnosis, treatment, vaccination, and effects on patients with cardiovascular disorders, was the most popular in terms of visitors to ACC.org's journal scans. In creating a COVID-19 Hub, ACC has tried to make all of this critical information available in one location, delivered in a timely manner, and always carefully vetted for quality. Hopefully 2022 will see us get our collective arms around this pandemic in such a way that we can again refocus on other "matters of the heart" that are so critical to our patients, families, staff and learners!

— Kim A. Eagle, MD, MACC

• Heterologous vs. Homologous Prime-Boost Schedules for COVID-19 Vaccines
• Hydroxychloroquine/Azithromycin and QT Prolongation in COVID-19
• Allergic Reactions After First Dose of Pfizer-BioNTech COVID-19 Vaccine
• SARS-CoV-2 Testing With Saliva vs. Nasopharyngeal Swabs
• 10-Year Mortality After PCI or CABG for Coronary Total Occlusion
• Possible Association Between COVID-19 Vaccine and Myocarditis
• Management of Stroke Patients With a PFO
• Azithromycin for Suspected COVID-19 in People at Increased Risk
• DOACs vs. Warfarin in Patients With Valvular Atrial Fibrillation
• Inhaled Budesonide for COVID-19 in People at High Risk

Top Clinical Trials

Deepak L. Bhatt, MD, MPH, FACC
Senior Associate Editor, Clinical Trials and News, ACC.org

It was a great year for clinical trial coverage on ACC.org! There were over 120,000 views of the top 10 trials for the year. We saw data released on sacubitril/valsartan, SGLT2 inhibitors, and anti-thrombotic strategies. Understandably, COVID-19 was a hot topic this year, and it was great to see cardiologists leading many of the informative trials. There were also trial updates that made the top 10 list—specifically, EMPEROR-Reduced, COMPASS, SPRINT, and DAPA-HF. In the past few months, we have added some new features for our learners to distinguish the new changes that resulted in our updated clinical trial summaries. We are always striving at ACC.org to make it as easy as possible for our learners to keep up with the rapid pace of new, relevant clinical information. If you have any feedback on how we can serve you better, we are all ears. On behalf of the ACC.org staff, Happy Holidays and a joyous New Year to you all!

— Deepak L. Bhatt, MD, MPH, FACC

• PARADISE-MI: Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction
• ACTION: AntiCoagulaTIon cOroNavirus
• EMPEROR-Preserved: Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction
• EMPEROR-Reduced (Update): Empagliflozin Outcome Trial in Patients With Chronic Heart Failure and a Reduced Ejection Fraction
• COMPASS (Update): Cardiovascular Outcomes for People Using Anticoagulation Strategies
• SPRINT (Update): Systolic Blood Pressure Intervention Trial
• DAPA-HF (Update): Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction
• LIFE: LCZ696 in Advanced Heart Failure
• ATLANTIS: Anti-Thrombotic Strategy to Lower All cardiovascular and Neurologic Ischemic and Hemorrhagic Events after Trans-Aortic Valve Implantation for Aortic Stenosis
• LAAOS III: Left Atrial Appendage Occlusion Study
• MASTER DAPT: Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated vs. Standard DAPT Regimen
• FLOWER-MI: Flow Evaluation to Guide Revascularization in Multivessel ST-Elevation Myocardial Infarction
• TALOS-AMI
• MICHELLE: Medically Ill Hospitalized Patients for COVID-19 Thrombosis Extended Prophylaxis With Rivaroxaban Therapy

Clinical Topics: Acute Coronary Syndromes, Anticoagulation Management, Arrhythmias and Clinical EP, Atherosclerotic Disease (CAD/PAD), Cardiac Surgery, Cardio-Oncology, Congenital Heart Disease and Pediatric Cardiology, Dyslipidemia, Geriatric Cardiology, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Noninvasive Imaging, Pericardial Disease, Prevention, Pulmonary Hypertension and Venous Thromboembolism, Sports and Exercise Cardiology, Stable Ischemic Heart Disease, Valvular Heart Disease, Vascular Medicine

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