Cardiovascular disease remains the leading cause of death in America, with well-established and identifiable risk factors. Modifiable risk factors are the primary driver for first cardiovascular event, and risk factor modification has been a significant driver for reduction of cardiovascular death in certain populations in recent decades. In this expert analysis, Richard Jones, MD, et al., offer an updated and concise clinician's guide to the “ABCDEs” of cardiovascular disease prevention – a guide first proposed in 2001 as a straightforward template for clinicians and patients to address key components of risk factor modification – based on updated guidelines and recent evidence for practical use. Read more.