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JACC in a Flash | Electronic Alerts For Managing AS, MR; More

Featured topics and Editors' Picks from all of ACC's JACC Journals.

Journal of the American College of Cardiology
Tonlamarsen Reduces Plasma AGT; Delivers Mixed Results For Uncontrolled BP

A monthly dose of the novel drug tonlamarsen significantly reduced plasma angiotensinogen (AGT) levels in patients with uncontrolled hypertension compared with a single dose of the drug followed by a placebo, but its impact on systolic blood pressure (SBP) was less clear, according to results from the KARDINAL trial presented at ACC.26 and simultaneously published in JACC.

Journal of the American College of Cardiology
Electronic Alerts Improve Management of AS, MR

Automated electronic clinician notification (ECN) alerts improved the timely evaluation and treatment of patients with severe aortic stenosis (AS) or mitral regurgitation (MR), according to findings from ALERT, presented at ACC.26 and simultaneously published in JACC.

Journal of the American College of Cardiology
Novel PCSK9 Inhibitor Reduces LDL-C in Patients Not Meeting Goals

The novel PCSK9 oral inhibitor enlicitide effectively lowered LDL-C in adults being treated with statins, demonstrating a potential role as an add-on option for patients not meeting LDL-C goals, according to the CORALreef AddOn trial presented at ACC.26 and simultaneously published in JACC.

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Resources

Clinical Topics: Dyslipidemia, Prevention, Valvular Heart Disease, Homozygous Familial Hypercholesterolemia, Lipid Metabolism, Nonstatins, Novel Agents, Hypertension, Mitral Regurgitation

Keywords: Cardiology Magazine, ACC Publications, CM-May-2026, ACC Annual Scientific Session, ACC26, New Orleans, Antihypertensive Agents, Angiotensinogen, Blood Pressure, Oligonucleotides, Antisense, Injections, Subcutaneous, Hypertension, Mitral Valve Insufficiency, Aortic Valve Insufficiency, Aortic Valve Stenosis, Quality Control, Patient Care Team, Cholesterol, LDL, Hypercholesterolemia, PCSK9